Cardioprotective effect of Solanum nigrum against doxorubicin induced cardiotoxicity-an experimental study

Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats

OBJECTIVE The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in ...

Cardioprotective Effect of Bioflavonoids against Isoproterenol Induced Cardiotoxicity in Rats

The present study was undertaken to explore the cardioprotective potential of bioflavonoids against isoproterenol induced cardiotoxicity in rats. Cardiotoxicity was induced by isoproterenol (85mg/kg body weight) in animals. Blood biochemical, hematological parameters, urinalysis and histopathological studies were carried to assess the cardio protective effect. Isoproterenol administration induc...

Cardioprotective Effect of Naringin against Doxorubicin Induced Cardiomyopathy in Rats

Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo

Doxorubicin (DOX) is considered as one of the best antineoplastic agents. However, its clinical use is restricted by its associated cardiotoxicity, which is mediated by the production of reactive oxygen species. In this study, 20(S)-ginsenoside Rh2 (Rh2) was explored whether it had protective effects against DOX-induced cardiotoxicity. In vitro study on H9C2 cell line, as well as in vivo invest...

Melatonin as an effective protector against doxorubicin-induced cardiotoxicity.

The present study was designed to explore the protective effects of melatonin and its analogs, 6-hydroxymelatonin and 8-methoxy-2-propionamidotetralin, on the survival of doxorubicin-treated mice and on doxorubicin-induced cardiac dysfunction, ultrastructural alterations, and apoptosis in mouse hearts. Whereas 60% of the mice treated with doxorubicin (25 mg/kg ip) died in 5 days, almost all the...